Loss of dopamine neuron terminals in antipsychotic-treated schizophrenia; relation to tardive dyskinesia
Identifieur interne : 001062 ( Main/Exploration ); précédent : 001061; suivant : 001063Loss of dopamine neuron terminals in antipsychotic-treated schizophrenia; relation to tardive dyskinesia
Auteurs : Philip Seeman [Canada] ; Michele Tinazzi [Italie]Source :
- Progress in neuro-psychopharmacology & biological psychiatry [ 0278-5846 ] ; 2013.
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- Pascal (Inist)
English descriptors
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Abstract
The in vivo labeling and brain imaging of dopamine transporters measure the density of dopamine neuron terminals in the human caudate/putamen. A review of such studies shows that the long-term use of antipsychotics had no major effect on the density of the dopamine terminals in individuals who had no tardive dyskinesia, but had reduced the density in those patients with tardive dyskinesia. In addition, the normal loss of dopamine terminals in healthy individuals was approximately 5% per decade. However, this rate of cell loss was apparently increased by approximately three-fold, to about 15% per decade, in schizophrenia patients using antipsychotics on a long-term basis, as measured by the in vivo imaging of the dopamine transporters in the dopamine neuron terminals. While an apparent reduction in dopamine transporters may result from reduced expression of the transporters secondary to antipsychotic treatment, the seemingly increased loss rate is consistent with the accumulation of antipsychotics in the neuromelanin of the substantia nigra, subsequent injury to the dopamine-containing neurons, and the development of extrapyramidal motor disturbances such as tardive dyskinesia or Parkinson's disease.
Affiliations:
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relation to tardive dyskinesia</title><author><name sortKey="Seeman, Philip" sort="Seeman, Philip" uniqKey="Seeman P" first="Philip" last="Seeman">Philip Seeman</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Pharmacology, University of Toronto, 260 Heath Street West, unit 605</s1><s2>Toronto M5P 3L6, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto M5P 3L6, Ontario</wicri:noRegion><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Toronto, 260 Heath Street West, unit 605</s1><s2>Toronto M5P 3L6, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto M5P 3L6, Ontario</wicri:noRegion><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurological, Neuropsychological, Morphological and Motor Sciences, University of Verona</s1><s3>ITA</s3><sZ>2 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Department of Neurological, Neuropsychological, Morphological and Motor Sciences, University of Verona</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Progress in neuro-psychopharmacology & biological psychiatry</title><title level="j" type="abbreviated">Prog. neuro-psychopharmacol. biol. psychiatr.</title><idno type="ISSN">0278-5846</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Progress in neuro-psychopharmacology & biological psychiatry</title><title level="j" type="abbreviated">Prog. neuro-psychopharmacol. biol. psychiatr.</title><idno type="ISSN">0278-5846</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antipsychotic</term><term>Caudate nucleus</term><term>Corpus striatum</term><term>Dopamine</term><term>Dopaminergic neuron</term><term>Dyskinesia</term><term>Late</term><term>Motor control</term><term>Neuroleptic</term><term>Pharmacotherapy</term><term>Psychotropic</term><term>Putamen</term><term>Schizophrenia</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Neurone dopaminergique</term><term>Neuroleptique</term><term>Antipsychotique</term><term>Pharmacothérapie</term><term>Schizophrénie</term><term>Dyskinésie</term><term>Tardif</term><term>Noyau caudé</term><term>Dopamine</term><term>Putamen</term><term>Corps strié</term><term>Psychotrope</term><term>Contrôle moteur</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The in vivo labeling and brain imaging of dopamine transporters measure the density of dopamine neuron terminals in the human caudate/putamen. A review of such studies shows that the long-term use of antipsychotics had no major effect on the density of the dopamine terminals in individuals who had no tardive dyskinesia, but had reduced the density in those patients with tardive dyskinesia. In addition, the normal loss of dopamine terminals in healthy individuals was approximately 5% per decade. However, this rate of cell loss was apparently increased by approximately three-fold, to about 15% per decade, in schizophrenia patients using antipsychotics on a long-term basis, as measured by the in vivo imaging of the dopamine transporters in the dopamine neuron terminals. While an apparent reduction in dopamine transporters may result from reduced expression of the transporters secondary to antipsychotic treatment, the seemingly increased loss rate is consistent with the accumulation of antipsychotics in the neuromelanin of the substantia nigra, subsequent injury to the dopamine-containing neurons, and the development of extrapyramidal motor disturbances such as tardive dyskinesia or Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Italie</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Seeman, Philip" sort="Seeman, Philip" uniqKey="Seeman P" first="Philip" last="Seeman">Philip Seeman</name></region><name sortKey="Seeman, Philip" sort="Seeman, Philip" uniqKey="Seeman P" first="Philip" last="Seeman">Philip Seeman</name></country><country name="Italie"><noRegion><name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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